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Publication History
Fetian, T., Grover, A., & Arndt, K. M. (2024). Histone H2B ubiquitylation: Connections to transcription and effects on chromatin structure. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1867(2), 195018.
Fetian, T., McShane, B. M., Horan, N. L., Shodja, D. N., True, J. D., Mosley, A. L., & Arndt, K. M. (2023). Paf1 complex subunit Rtf1 stimulates H2B ubiquitylation by interacting with the highly conserved N-terminal helix of Rad6. Proceedings of the National Academy of Sciences, 120(22), e2220041120.
Ellison, M. A., Namjilsuren, S., Shirra, M. K., Blacksmith, M. S., Schusteff, R. A., Kerr, E. M., Fang, F., Xiang, Y., Shi, Y., & Arndt, K. M. (2023). Spt6 directly interacts with Cdc73 and is required for Paf1 complex occupancy at active genes in Saccharomyces cerevisiae. Nucleic Acids Research, 51(10), 4814–4830.
Shirra, M. K., Kocik, R. A., Ellison, M. A., & Arndt, K. M. (2021). Opposing functions of the Hda1 complex and histone H2B mono-ubiquitylation in regulating cryptic transcription in Saccharomyces cerevisiae. G3: Genes, Genomes, Genetics, 11(11).
Kaplan, C. D., & Arndt, K. M. (2021). A PICture is worth a thousand words (and ten references). Cell, 184(15), 3850–3851.
Francette, A. M., Tripplehorn, S. A., & Arndt, K. M. (2021). The Paf1 Complex: A Keystone of Nuclear Regulation Operating at the Interface of Transcription and Chromatin. Journal of Molecular Biology, 433(14), 166979.
Ellison, M. A., Walker, J. L., Ropp, P. J., Durrant, J. D., and Arndt, K. M. (2020) MutantHuntWGS: a pipeline for identifying Saccharomyces cerevisiae mutations. G3: Genes, Genomes, Genetics. 10:3009-3014
Hildreth, A.E., Ellison, M.A., Francette, A.M., Seraly, J.M., Lotka, L.M., Arndt, K.M. (2020) The Nucleosome DNA Entry-Exit Site Is Important for Transcription Termination and Prevention of Pervasive Transcription. eLife 9, e57757.
Cucinotta, C.E., Hildreth, A.E., McShane, B.M., Shirra, M.K., and Arndt, K.M. (2019) The nucleosome acidic patch directly interacts with subunits of the Paf1 and FACT complexes and controls chromatin architecture in vivo. Nucleic Acids Research 47:8410-8423
Ellison, M.A., Lederer, A.R., Warner, M.H., Mavrich, T.N., Raupach, E.A., Heisler, L.E., Nislow, C., Lee, M.T., and Arndt, K.M. (2019) The Paf1 complex broadly impacts the transcriptome of Saccharomyces cerevisiae. Genetics 212:711-728
Hildreth, A.E. and Arndt, K.M. (2017) A transcriptional switch controls meiosis. eLife 2017;6:e31911
Van Oss S.B., Cucinotta, C.E., and Arndt, K.M. (2017) Emerging insights into the roles of the Paf1 complex in gene regulation. Trends Bioch. Sci., 42:788-798
Van Oss, S.B., Shirra, M. K., Bataille, A. R., Wier, A. D., Yen, K., Vinayachandran, V., Byeon, I.-J. L., Héroux, A., Cucinotta, C. E., Jeon, J., Kim, J., VanDemark, A. P., Pugh, B. F., and Arndt, K. M. (2016) The histone modification domain of Paf1 complex subunit Rtf1 directly stimulates H2B ubiquitylation through an interaction with Rad6. Molecular Cell 64:815-825
Cucinotta, C.E. and Arndt, K.M. (2016) SnapShot: Transcription Elongation. Cell 166: 1058
Raupach, E.A., Martens, J.A., and Arndt, K.M. (2016) Evidence for regulation of ECM3 expression by intergenic transcription and methylation of histone H3 lysine 4 in Saccharomyces cerevisiae. G3: Genes, Genomes, Genetics 6: 2971-2981.
Cucinotta, C. E., Young, A. N., Klucevsek, K. M., and Arndt, K. M. (2015) The nucleosome acidic patch regulates the H2B K123 monoubiquitylation cascade and transcription elongation in Saccharomyces cerevisiae. PLOS Genetics DOI:10.1371/journal.pgen.1005420.
Arndt, K.M. and Reines, D. (2015) Termination of Transcription of Short Noncoding RNAs by RNA Polymerase II. Annu. Rev. Biochem., 84:22.1–22.24
Wier, A.D., Mayekar, M.K., Heroux, A., Arndt, K.M., VanDemark, A.P. (2013) The structural basis for Spt5-mediated recruitment of the Paf1 complex to chromatin. Proc. Natl. Acad. Sci. USA 110:17290-17295
Mayekar, M. K., Gardner, R. G., and Arndt K. M. (2013) The recruitment of the Saccharomyces cerevisiae Paf1 complex to active genes requires a domain of Rtf1 that directly interacts with the Spt4-Spt5 complex. Mol. Cell Biol., 33: 3259-3273
Tomson, B.N., Crisucci, E.M., Heisler, L.E., Gebbia, M., Nislow, C. and Arndt, K.M. (2013) Effects of the Paf1 complex and histone modifications on snoRNA 3'-end formation reveal broad and locus-specific regulation. Mol. Cell. Biol., 33:170-182
Tomson, B.N. and Arndt, K.M. (2013) The many roles of the conserved eukaryotic Paf1 complex in regulating transcription, histone modifications, and disease states. Biochim. Biophys. Acta 1829:116-126
Piro, A. S., Mayekar, M. K., Warner, M. H., Davis, C. P., and K. M. Arndt (2012) Small region of Rtf1 protein can substitute for complete Paf1 complex in facilitating global histone H2B ubiquitylation in yeast. Proc. Natl. Acad. Sci. USA 109:10837-10842
Klucevsek, K.M., Braun, M.A., and K.M. Arndt (2012) The Paf1 complex subunit Rtf1 buffers cells against the toxic effects of [PSI+] and defects in Rkr1-dependent protein quality control in Saccharomyces cerevisiae. Genetics 191: 1107-1118
Amrich, C.G., Davis, C.P., Rogal, W.P., Shirra, M.K., Heroux, A., Gardner, R.G., Arndt, K.M. and VanDemark, A.P. (2012) The Cdc73 subunit of the Paf1 complex contains a C-terminal Ras-like domain that promotes association of the Paf1 complex with chromatin. J. Biol. Chem., 287:10863-10875.
Crisucci, E.M. and Arndt, K.M. (2012) Paf1 restricts Gcn4 occupancy and antisense transcription at the ARG1 promoter. Mol. Cell Biol. 32:1150-1163
Crisucci, E.M. and K.M. Arndt (2011) The roles of the Paf1 complex and associated histone modifications in regulating gene expression. Genetics Research International 2011:doi:10.4061/2011/707641
Crisucci, E.M. and K.M. Arndt (2011) The Paf1 complex represses ARG1 transcription in Saccharomyces cerevisiae by promoting histone modifications. Euk. Cell 10:712-723
Tomson, B.N., C.P. Davis, M.H. Warner, and K.M. Arndt (2011) Identification of a role for histone H2B ubiquitylation in non-coding RNA 3'-end formation through mutational analysis of Rtf1 in S. cerevisiae. Genetics 188: 273-289
Shirra, M.K., R.R. McCartney, C. Zhang, K.M. Shokat, M.C. Schmidt, and K.M. Arndt (2008) A chemical genomics study identifies Snf1 as a repressor of GCN4 translation. J. Biol. Chem. 283:35889-35898
Rubenstein, E.M., R.R. McCartney, C. Zhang, K.M. Shokat, M.K. Shirra, K.M. Arndt, and M.C. Schmidt (2008) Access denied: Snf1 activation loop phosphorylation is controlled by availability of the phosphorylated threonine 210 to the PP1 phosphatase. J. Biol. Chem. 283:222-230
Arndt, K.M. (2007) Molecular biology: genome under surveillance. Nature 450:959-960
Chu, Y., R. Simic, M.H. Warner, K.M. Arndt, and G. Prelich (2007) Regulation of histone modification and cryptic transcription by the Bur1 and Paf1 complexes. EMBO J. 26:4646-4656
Warner, M.H., K.L. Roinick, and K.M. Arndt (2007) Rtf1 is a multifunctional component of the Paf1 complex that regulates gene expression by directing cotranscriptional histone modification. Mol. Cell Biol. 27:6103-6115
Braun, M.A., P.J. Costa, E.M. Crisucci, and K.M. Arndt (2007) Identification of Rkr1, a nuclear RING domain protein with functional connections to chromatin modification in Saccharomyces cerevisiae. Mol. Cell. Biol. 27:2800-2811
Sheldon, K.E., D.M. Mauger, and K.M. Arndt (2005) A requirement for the Saccharomyces cerevisiae Paf1 Complex in snoRNA 3' end formation. Mol. Cell 20:225-236
Arndt, K., and F. Winston (2005) An unexpected role for ubiquitylation of a transcriptional activator. Cell 120:733-734
Shirra, M.K., S.E. Rogers, D.E. Alexander, and K.M. Arndt (2005) The Snf1 protein kinase and Sit4 protein phosphatase have opposing functions in regulating TBP association with the Saccharomyces cerevisiae INO1 promoter. Genetics 169:1957-1972
Arndt, K.M., and C.M. Kane (2003) Running with RNA polymerase: eukaryotic transcript elongation. Trends Genet. 19:543-550
Simic, R., D.L. Lindstron, H.G. Tran, K.L. Roinick, P.J. Costa, A.D. Johnson, G.A. Hartzog, and K.M. Arndt (2003) Chromatin remodeling protein Chd1 interacts with transcription elongation factors and localizes to transcribed genes. EMBO J. 22:1846-4856
Spencer, J.V., and K.M. Arndt (2002) A TATA binding protein mutant with increased affinity for DNA directs transcription from a reversed TATA sequence in vivo. Mol. Cell. Biol. 22:8744-8755
Squazzo, S.L., P.J. Costa, D. Lindstrom, K.E. Kumer, R. Simic, J.L. Jennings, A.K. Link, K.M. Arndt, and G. Hartzog (2002) The Paf1 complex physically and functionally associates with transcription elongation factors in vivo. EMBO J. 21:1764-1774
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